Chiral Structured Illumination Microscopy

TL;DR

This paper introduces a novel microscopy technique that combines structured illumination and optical chirality engineering to achieve super-resolution imaging of chiral domains.

Contribution

It presents a new chiral imaging modality that integrates structured illumination microscopy with circular dichroism detection, enabling sub-diffraction resolution of chiral structures.

Findings

Theoretically demonstrated the feasibility of the method.

Proposed optical chirality engineering approach for far-field optics.

Achieved super-resolution imaging of chiral domains.

Abstract

We propose a chiral imaging modality based on optical chirality engineering, fluorescence-detected circular dichroism and structured illumination microscopy. In this method, the optical chirality of the illumination is structured and the circular dichroism dependent fluorescence is detected. With image reconstruction, the spatial distribution of chiral domains can be obtained at sub-diffraction limited resolution. We theoretically demonstrate this method and discuss the feasibility using an optical chirality engineering approach based on far-field optics.