Shuyi, A Name After Dendritic Cell-mediated Immunological Memory
Yiqiang Wang

TL;DR
This paper discusses the concept of immunological memory extending beyond B and T cells, highlighting recent evidence of dendritic cells' memory-like responses and the author's early efforts to identify dendritic cell-mediated memory.
Contribution
The paper presents historical insights and experimental efforts to identify dendritic cell-mediated immunological memory, proposing it as a potential third class of memory-competent immune cells.
Findings
Dendritic cells exhibit a memory-like response after pathogen exposure.
Histone modification plays a role in dendritic cell training.
Dendritic cell memory persists weeks after initial challenge.
Abstract
Immunological memory is a fundamental theory of modern immunology, which is traditionally believed to be mediated only by B and T lymphocytes that recognize antigen epitopes in a receptor-restricted manner. During the last decade data accumulated to show that monocytes and macrophages, the two main initiators of innate immune response, also built up a "memory" to antigens they encountered, though in most concerned publications a different wording (i.e. "train" or"educate") was utilized to describe this feature. More recently, Hole et al demonstrated a "memory-like" response of dendritic cells (DCs). In brief, if fungal-challenged mice could develop a protective immune response, DCs immediately (in 3 weeks) isolated from those mice would manifest a pro-inflammatory phenotype. Even after the mice were allowed to rest for 10 weeks, DCs from them still exhibited an enhanced immune…
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Taxonomy
TopicsImmune responses and vaccinations · Vaccine Coverage and Hesitancy · Viral Infections and Outbreaks Research
