# Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity

## TL;DR

This paper models electromagnetic fields in a bioreactor to analyze how low-frequency electromagnetic forces may influence cell behavior through mechanical effects, aiding understanding of electromagnetic stimulation mechanisms.

## Contribution

It provides detailed numerical dosimetry of electromagnetic fields in a bioreactor and links these forces to biological mechanisms via the tensegrity-mechanotransduction theory.

## Key findings

- Magnetic induction field reaches about 3.3 mT
- Induced mechanical forces include compression and traction
- Potential link between electromagnetic forces and cell mechanotransduction

## Abstract

We have implemented field models and performed a detailed numerical dosimetry inside our extremely-low-frequency electromagnetic bioreactor which has been successfully used in $\textit{in vitro}$ Biotechnology and Tissue Engineering researches. The numerical dosimetry permitted to map the magnetic induction field (maximum module equal to about 3.3 mT) and to discuss its biological effects in terms of induced electric currents and induced mechanical forces (compression and traction). So, in the frame of the tensegrity-mechanotransduction theory of Ingber, the study of these electromagnetically induced mechanical forces could be, in our opinion, a powerful tool to understand some effects of the electromagnetic stimulation whose mechanisms remain still elusive.

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Source: https://tomesphere.com/paper/1908.01234