# Optimal control of stochastic phase-field models related to tumor growth

**Authors:** Carlo Orrieri, Elisabetta Rocca, Luca Scarpa

arXiv: 1908.00306 · 2021-01-19

## TL;DR

This paper develops a stochastic phase-field model for tumor growth, proving well-posedness and analyzing optimal control strategies for drug administration using advanced mathematical techniques.

## Contribution

It introduces a novel stochastic model coupling tumor dynamics with nutrient diffusion and establishes optimal control conditions for treatment strategies.

## Key findings

- Proved strong well-posedness of the stochastic system
- Established existence of optimal control strategies
- Derived first-order optimality conditions

## Abstract

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.

## Full text

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## References

60 references — full list in the complete paper: https://tomesphere.com/paper/1908.00306/full.md

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Source: https://tomesphere.com/paper/1908.00306