Continuous Radio Amplification by Stimulated Emission using Parahydrogen Induced Polarization (PHIP-RASER) at 14 Tesla

TL;DR

This paper reports a continuous high-frequency NMR RASER using PHIP-induced hyperpolarization at 14 Tesla, achieving long-lasting signal emission with high resolution, and demonstrates its accessibility with standard equipment.

Contribution

It introduces a novel continuous NMR RASER at high field using PHIP, with a comprehensive simulation and demonstration on standard equipment.

Findings

Continuous 1H NMR RASER emitted for over 10 minutes.

Achieved chemical shift resolution with 2 ppb linewidth.

Simulation successfully reproduces experimental results.

Abstract

Nuclear Magnetic Resonance (NMR) is an intriguing quantum-mechanical effect that is used for daily life medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents that enables real-time imaging of metabolism in vivo. In physics, hyperpolarization has enabled an NMR RASER using a custom low-field setup and high-Q coils only recently. Expanding on this discovery, we report the finding of a RASER emitting 1H NMR signal continuously for more than 10 min at a high frequency of 600 MHz. Full chemical shift resolution is maintained and a linewidth of 2 ppb was achieved. A new simulation of a RASER effect in a coupled two spin-1/2 system was implemented and reproduced experimental findings. The effect was found using standard equipment only; no dedicated setup is necessary, making the NMR RASER accessible to a wide group of researchers.