# An equilibrium model for ribosome competition

## TL;DR

This paper introduces an equilibrium model to analyze how ribosome availability and transcript demand influence gene expression regulation, providing insights into cellular physiology and potential new regulatory mechanisms.

## Contribution

It presents a novel equilibrium framework for understanding ribosome competition and its impact on gene expression regulation in cells.

## Key findings

- Highlights qualitative behaviors of ribosome demand and supply balance
- Suggests new gene regulation mechanisms based on ribosome competition
- Provides insights into cellular physiology related to ribosome allocation

## Abstract

The number of ribosomes in a cell is considered as limiting, and gene expression is thus largely determined by their cellular concentration. In this work we develop a toy model to study the trade-off between the ribosomal supply and the demand of the translation machinery, dictated by the composition of the transcript pool. Our equilibrium framework is useful to highlight qualitative behaviours and new means of gene expression regulation determined by the fine balance of this trade-off. We also speculate on the possible impact of these mechanisms on cellular physiology.