# Estimating regional cerebral blood flow using resting-state functional MRI via machine learning

## TL;DR

This study presents a machine learning approach to estimate regional cerebral blood flow from resting-state fMRI, providing a non-invasive alternative to perfusion MRI, with potential applications in aging and neurodegenerative disease assessment.

## Contribution

Introduces a novel machine learning framework that estimates cerebral blood flow from resting-state fMRI spectral features, validated against arterial spin labeling data.

## Key findings

- Significant correlation between estimated and actual CBF in multiple brain regions.
- Estimated CBF correlates with cognitive scores and differs between normal and MCI groups.
- Method outperforms frequency ranges [0.01-0.10] and [0.01-0.20] Hertz in correlation strength.

## Abstract

Perfusion MRI is an important modality in many brain imaging protocols, since it probes cerebrovascular changes in aging and many diseases; however, it may not be always available. Here we introduce a method that seeks to estimate regional perfusion properties using spectral information of resting-state functional MRI (rsfMRI) via machine learning. We used pairs of rsfMRI and arterial spin labeling (ASL) images from the same elderly individuals with normal cognition (NC; n = 45) and mild cognitive impairment (MCI; n = 26), and built support vector machine models aiming to estimate regional cerebral blood flow (CBF) from the rsfMRI signal alone. This method demonstrated higher associations between the estimated CBF and actual CBF (ASL-CBF) at the total lobar gray matter (r = 0.40; FDR-p = 1.9e-03), parietal lobe (r = 0.46, FDR-p = 8e-04), and occipital lobe (r = 0.35; FDR-p = 0.01) using rsfMRI signals of frequencies [0.01-0.15] Hertz compared to frequencies [0.01-0.10] Hertz and [0.01-0.20] Hertz, respectively. We further observed significant associations between the estimated CBF and actual CBF in 24 regions of interest (p < 0.05), with the highest association observed in the superior parietal lobule (r = 0.50, FDR-p = 0.002). Moreover, the estimated CBF at superior parietal lobule showed significant correlation with the mini-mental state exam (MMSE) score (r = 0.27; FDR-p = 0.04) and decreased in MCI with lower MMSE score compared to NC group (FDR-p = 0.04). Overall, these results suggest that the proposed framework can obtain estimates of regional perfusion from rsfMRI, which can serve as surrogate perfusion measures in the absence of ASL.

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Source: https://tomesphere.com/paper/1907.08145