# Topological Information Data Analysis

## TL;DR

This paper introduces topological information data analysis methods to quantify complex statistical interactions in data, revealing insights into independence, co-variation, and clustering, with applications in genetics and biology.

## Contribution

It develops new topological and information-theoretic tools for analyzing multivariate data, especially in biological systems, addressing estimation biases and demonstrating practical applications.

## Key findings

- Vanishing I_k indicates statistical independence.
- Maximal I_k identifies co-varying variables.
- Application to genetic data reveals biologically relevant subtypes.

## Abstract

This paper presents methods that quantify the structure of statistical interactions within a given data set, and was first used in \cite{Tapia2018}. It establishes new results on the k-multivariate mutual-informations (I_k) inspired by the topological formulation of Information introduced in. In particular we show that the vanishing of all I_k for 2\leq k \leq n of n random variables is equivalent to their statistical independence. Pursuing the work of Hu Kuo Ting and Te Sun Han, we show that information functions provide co-ordinates for binary variables, and that they are analytically independent on the probability simplex for any set of finite variables. The maximal positive I_k identifies the variables that co-vary the most in the population, whereas the minimal negative I_k identifies synergistic clusters and the variables that differentiate-segregate the most the population. Finite data size effects and estimation biases severely constrain the effective computation of the information topology on data, and we provide simple statistical tests for the undersampling bias and the k-dependences following. We give an example of application of these methods to genetic expression and unsupervised cell-type classification. The methods unravel biologically relevant subtypes, with a sample size of 41 genes and with few errors. It establishes generic basic methods to quantify the epigenetic information storage and a unified epigenetic unsupervised learning formalism. We propose that higher-order statistical interactions and non identically distributed variables are constitutive characteristics of biological systems that should be estimated in order to unravel their significant statistical structure and diversity. The topological information data analysis presented here allows to precisely estimate this higher-order structure characteristic of biological systems.