Local well-posedness in the Wasserstein space for a chemotaxis model coupled to Navier-Stokes equations
Kyungkeun Kang, Haw Kil Kim

TL;DR
This paper proves the local well-posedness of a coupled chemotaxis and fluid dynamics model in the Wasserstein space, improving existence results by weakening initial data assumptions.
Contribution
It refines the existence theory for a Keller-Segel-Navier-Stokes system by strengthening the analysis of the Fokker-Planck component in Wasserstein space.
Findings
Existence of solutions under weaker initial data conditions
Refined analysis of Fokker-Planck equation in Wasserstein space
Construction of solutions with biological density in absolutely continuous curves
Abstract
We consider a coupled system of Keller-Segel type equations and the incompressible Navier-Stokes equations in spatial dimension two and three. In the previous work [19], we established the existence of a weak solution of a Fokker-Plank equation in the Wasserstein space using the optimal transportation technique. Exploiting this result, we constructed solutions of Keller-Segel-Navier-Stokes equations such that the density of biological organism belongs to the absolutely continuous curves in the Wasserstein space. In this work, we refine the result on the existence of a weak solution of a Fokker-Plank equation in the Wasserstein space. As a result, we construct solutions of Keller-Segel-Navier-Stokes equations under weaker assumptions on the initial data.
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TopicsMathematical Biology Tumor Growth · Effects of Radiation Exposure · advanced mathematical theories
Local well-posedness in the Wasserstein space for a chemotaxis model coupled to Navier-Stokes equations
Kyungkeun Kang and Haw Kil Kim
Abstract
We consider a coupled system of Keller-Segel type equations and the incompressible Navier-Stokes equations in spatial dimension two and three. In the previous work [17], we established the existence of a weak solution of a Fokker-Plank equation in the Wasserstein space using the optimal transportation technique. Exploiting this result, we constructed solutions of Keller-Segel-Navier-Stokes equations such that the density of biological organism belongs to the absolutely continuous curves in the Wasserstein space. In this work, we refine the result on the existence of a weak solution of a Fokker-Plank equation in the Wasserstein space. As a result, we construct solutions of Keller-Segel-Navier-Stokes equations under weaker assumptions on the initial data.
2010 AMS Subject Classification : 35K55, 75D05, 35Q84, 92B05
Keywords : chemotaxis, Navier-Stokes equations, Fokker-Plank equations, Wasserstein space
1 Introduction
In this paper, we study an aerotaxis model formulating the dynamics of oxygen, swimming bacteria, and viscous incompressible fluids in , , .
[TABLE]
[TABLE]
[TABLE]
Here , , and denote the biological cell concentration, oxygen concentration, fluid velocity, and scalar pressure, respectively, where indicates the set of non-negative real numbers. The oxygen consumption rate and the aerobic sensitivity are nonnegative as functions of , namely such that and and the time-independent function denotes the potential function, e.g., the gravitational force or centrifugal force. Initial data are given by with and . Tuval et al. proposed in [27], describing behaviors of swimming bacteria, Bacillus subtilis (see also [7]).
The above system (1.1)-(1.3) seems to have similarities to the classical Keller-Segel model suggested by Patlak[24] and Keller-Segel[18, 19], which is given as
[TABLE]
where is the biological cell density and is the concentration of chemical attractant substance. Here, is the chemotatic sensitivity, and and are the decay and production rate of the chemical, respectively. The system (1.4) has been comprehensively studied and results are not listed here (see e.g. [13, 16, 22, 23, 29] and the survey papers [14, 15]).
We remark that in the case that the effect of fluids is absent, i.e., and , the system (1.1)-(1.3) becomes a Keller-Segel type model with the negative term . It is due to the fact that the oxygen concentration is consumed, while the chemical substance is produced by in the Keller-Segel system (1.4).
Our main objective is to establish the existence of solution for the system (1.1)-(1.3) in the Wasserstein space, which will be described later in detail.
We review some known results related to well-posedness of solutions for the system (1.1)-(1.3). Existence of local-in-time solutions was proven for bounded domains in . It was shown in [10] that smooth solutions exist globally in time, provided that initial data are very near constant steady states and , hold the following conditions:
[TABLE]
Global well-posedness of regular solutions was proved in [30] for large initial data for bounded domains in with boundary conditions under a similar conditions as (1.5) on and :
[TABLE]
Different structure conditions are given in [1], where (1.6) is slightly relaxed, in case that is a constant.
In [3, Theorem 1.1] the first author et al. constructed unique regular solutions for general and in following function classes:
[TABLE]
in case that and initial data belong to
[TABLE]
In addition, if and satisfy the following conditions, motivated by experimental results in [7] and [27] (compare to (1.5) or (1.6)): There is an such that
[TABLE]
global-in-time regular solutions exist in with no smallness of the initial data (see [3, Theorem 1.3]). We remark that was shown in [6] that if is sufficiently small, global well-posedness and temporal decays can be established, in only case that . One can also consult [5], [31] and [4] with reference therein for temporal decay and asymptotics, and also refer to e.g. [8], [11], [26] and [9] for the nonlinear diffusion models of a porous medium type.
Our main ingredient is to establish existence of weak solutions for the Fokker-Plank equations in the Wasserstein space. Compared to previous result, in [17], the authors assumed that is in and constructed cell concentration in the Wasserstein space. More precisely, by understanding the following Fokker-Planck equation as an absolutly continuous curve in the Wasserstein space,
[TABLE]
we solved (1.10) under the assumption (refer Theorem 1.1 in [17])
[TABLE]
As a result, by exploiting the above result with , we constructed the solution of Keller-Segel-Navier-Stokes system (1.1)-(1.3) under the assumption (refer Theorem 1.2 in [17])
[TABLE]
for any and .
In this paper, by exploiting approximation argument to (1.10) and being able to control the uniform speed of approximated absolutely continuous curves in the Wasserstein space, we solve the Fokker-Plank equation (1.10) under the weaker regularity assumption on the velocity field
[TABLE]
This is certainly weaker than (1.11) and it turns out that initial condition can be in a function space larger than .
More precise statement of the above result is stated in Theorem 1.
Theorem 1
Let and . Suppose
[TABLE]
Assume further that
[TABLE]
Then, there exists an absolutely continuous curve such that for all , and solves (1.10) in the sense of distributions, namely, for any
[TABLE]
and
[TABLE]
where the constant
Furthermore, if for then we have
[TABLE]
Remark 1
The limiting case, , in (1.15) can be included, and it requres, however, an extra smallness of its norm, i.e. there is an such that . Thus, we do not consider such case in Theorem 1.
With the aid of Theorem 1, we construct weak solutions for the aerotaxis-fluid model (1.1)-(1.3) in the Wasserstein space. For convenience, we introduce some function classes, which are defined as
[TABLE]
[TABLE]
where the function spaces and are equipped with the following norms:
[TABLE]
[TABLE]
Next, we establish the existence of solutions in the classes for the system (1.1)-(1.3). Our result reads as follows:
Theorem 2
Let , and . Suppose that are all non-negative and , and , for . Let the initial data be given as
[TABLE]
Then there exists and a unique weak solution of (1.1)-(1.3) such that
[TABLE]
where . Furthermore, we have
[TABLE]
Here the constant in (1.25) depends on
[TABLE]
where and are numbers that come from Theorem 1 when .
We make several comments for Theorem 2.
- (i)
It was shown in [20] that if the initial data are sufficiently small in invariant classes, it is known that mild solutions globally exist in time. More precisely, in case and under the assumption that is small (if , is relaxed by ), mild solutions exist globally in time, e.g. (see [20, Theorem 1]). The initial data in Theorem 2 are assumed to be subcritical, and thus stronger than those in [20]. Nevertheless, the weak solutions constructed in Theorem 2 is for the case of large data, not small data and furthermore, the estimate (1.25) is valid continuously up to initial time (compare to [20]).
- (ii)
It is not clear if local well-posedness can be established in case that with no smallness in -norm or not, We also do not know that local well-posedness can be extened to global well-posedness, when for , and thus we leave these as open questions.
- (iii)
The results of Theorem 2 also hold for . We do not, however, include the case for the system (1.1)-(1.3), since a dimension higer than three doesn’t seem to be empirically relavant.
- (iv)
We note that, due to regularized effect of diffusion, solutions in Theorem 2 become regular in for all , assuming additionally that are belong to .
- (vi)
The initial data and can be relaxed compared to assumptions in (1.23). To be more precise, in (1.23) can be replaced by defined by
[TABLE]
where is the Heat or Stokes operator (see e.g. [12, Theorem 2.3]).
This paper is organized as follows. In Section 2, preliminary works are introduced. Section 3 and Section 4 are devoted to proving Theorem 1 and Theorem 2, respectively.
2 Preliminaries
2.1 Wasserstein space
In this subsection, we introduce the Wasserstein space and remind some properties of it. For more detail, readers may refer to e.g. [2] and [28].
Definition 3
Let be a probability measure on . Suppose there is a measurable map . Then, the map induces a probability measure on which is defined as
[TABLE]
We denote, for convenience, and say that is the push-forward of by .
Let us denote by the set of all Borel probability measures on with a finite second moment. For , we consider
[TABLE]
where denotes the set of all Borel probability measures on which has and as marginals, i.e.
[TABLE]
for every Borel set
Equation (2.1) defines a distance on which is called the Wasserstein distance. Equipped with the Wasserstein distance, is called the Wasserstein space. It is known that the infimum in the right hand side of Equation (2.1) always achieved. We will denote by the set of all which minimize the expression.
If is absolutely continuous with respect to the Lebesgue measure then there exists a convex function such that is the unique element of , that is, .
Definition 4
Let . We say that is convex in if for every couple there exists an optimal plan such that
[TABLE]
where is a constant speed geodesic between and defined as
[TABLE]
Here, and are the first and second projections of onto defined by
[TABLE]
As we have seen in Theorem 1 and Theorem 2, we will find a solution of equation (1.1) in the class of absolutely continuous curves in the Wasserstein space. Now, we introduce the definition of absolutely continuous curve and its relation with the continuity equation.
Definition 5
Let be a curve. We say that is absolutely continuous and denote it by , if there exists such that
[TABLE]
If , then the limit
[TABLE]
exists for -a.e . Moreover, the function belongs to and satisfies
[TABLE]
for any satisfying (2.2). We call by the metric derivative of .
Lemma 6** ([2], Theorem 8.3.1)**
If then there exists a Borel vector field such that
[TABLE]
and the continuity equation
[TABLE]
holds in the sense of distribution sense.
Conversely, if a weak continuous curve satisfies the continuity equation (2.4) for some Borel vector field with , then is absolutely continuous and for -a.e .*
Notation : In Lemma 6, we use notation and . Throughout this paper, we keep this convention, unless any confusion is to be expected, and a usual notation is adopted for temporal derivative, i.e. and .
Lemma 7
Let be a sequence and suppose there exists such that
[TABLE]
for all Then there exists a subsequnece such that
[TABLE]
for some satisfying
[TABLE]
Proof. Refer proposition 3.3.1 in [2] with the fact that is weak* compact.
2.2 Estimates of heat equation and Stokes system
We first recall some estimates of the heat equation, which are useful for our purpose. For convenience, we denote for .
Let be the solution of the following heat equation:
[TABLE]
where is a d-dimensional vector field and is a scalar function.
Let with and . Suppose that , and , where with . Then, it follows that
[TABLE]
The estimate (2.9) is well-known, but, for clarity, we give a sketch of its proof.
Indeed, we decompose such that , satisfies
[TABLE]
[TABLE]
[TABLE]
Via representation formula of the heat equation for example ,
[TABLE]
where is the heat kernel. Due to maximal regularity, we observe that
[TABLE]
On the other hand, it is easy to see that
[TABLE]
We suffices to show that
[TABLE]
Indeed, via representation formula of the heat equation, we have
[TABLE]
Using potential estimate, we have
[TABLE]
Integrating in time, we obtain
[TABLE]
We deduce the estimate (2.9).
Remark 2
In case that , for any with , and
[TABLE]
Compared to (2.9), the case that is also included in (2.11).
We also remind the maximal regularity of heat equation and Stoke system (see e.g. [21] and [25]). Let be a solution of
[TABLE]
[TABLE]
Then, the following a priori estimate holds for any
[TABLE]
In case of the following Stokes system
[TABLE]
[TABLE]
Similarly, it is known that the following a priori estimate holds:
[TABLE]
where .
In next lemma, we obtain some estimates of functions in , which we will use later.
Lemma 8
Let and . Assume that and are numbers satisfying
[TABLE]
Suppose that and . Then,
[TABLE]
[TABLE]
Proof. Indeed, we consider
[TABLE]
Via representation formula of the heat equation, we have
[TABLE]
where is the heat kernel. Since , direct computations show that
[TABLE]
[TABLE]
[TABLE]
Since the other estimates can be similarly verified, we skip its details.
3 Proof of Theorem 1
In this section, we provide the proof of Theorem 1. We start with some a priori estimates.
Lemma 9
Let and . Suppose that a non-negative function and a vector field satisfy
[TABLE]
Let and be a solution of
[TABLE]
Then we have
[TABLE]
Proof. We multiply (3.1) with and integrate w.r.t spacial variable to get
[TABLE]
Due to the Gagliardo-Nirenberg inequality, namely
[TABLE]
the righthand side is estimated as follows:
[TABLE]
[TABLE]
Therefore, we obtain
[TABLE]
which yields
[TABLE]
This completes the proof.
Next, we estimate the Wasserstein distance, which turns out to be Hölder continuous.
Lemma 10
Let and . Suppose that a non-negative function and a vector field satisfy
[TABLE]
Let be a solution of
[TABLE]
Then we have
[TABLE]
*for some positive constant . *
Proof. First, we estimate the second moment of . We multiply to (3.7) and integrate
[TABLE]
where we used
[TABLE]
Here which will be specified later.
Next, we prove . To do this, we rewrite (3.7) as follows
[TABLE]
We then show that
[TABLE]
Once we obtain (3.11), from Lemma 6, we are done with proving . Thus, it suffices to prove (3.11). We multiply to (3.7) and then integrate
[TABLE]
where we used that
[TABLE]
We note there exist constants (independent of ) such that
[TABLE]
Combining (3.9) and (3.12), we have
[TABLE]
[TABLE]
On the other hand,
[TABLE]
From (3.15) and (3.16), we get
[TABLE]
[TABLE]
Integrating in time, we have
[TABLE]
We denote
[TABLE]
[TABLE]
Then
[TABLE]
Taking sufficiently small, it follows that
[TABLE]
Gronwall’s inequality implies that
[TABLE]
Therefore, we obtain
[TABLE]
where depends on
[TABLE]
It follows that
[TABLE]
which leads to
[TABLE]
Finally, for any , we have
[TABLE]
Due to (3.23), the constant in (3.24) only depends on
[TABLE]
Hence, we have
[TABLE]
which concludes (3.8).
Now we present the proof of Theorem 1.
**Proof of Theorem 1 ** Suppose and with . By exploiting truncation and mollification, we may choose a sequence of vector fields such that
[TABLE]
Using truncation, mollification and normalization in a similar way, we choose a sequence of functions satisfying
[TABLE]
From Theorem of [17], we have which is a solution of
[TABLE]
that is,
[TABLE]
for every .
Step 1. We claim that curves are equi-continuous.
First, we exploit Lemma 10 and get
[TABLE]
where only depending on
[TABLE]
Due to (3.26) and (3.27), we conclude
[TABLE]
where only depending on
[TABLE]
Step 2. Estimation (3.32) says that curves are equi-continuous and hence there exists a curve such that , as (up to subsequence)
[TABLE]
Due to (3.23), we note that the uniform entropy bound on implies for all . Furthermore, the convergence in (3.26) gives us
[TABLE]
for any . Indeed, we have
[TABLE]
where
[TABLE]
Due to (3.16), we note that
[TABLE]
where the last inequality follows from (3.23). Combining (3.37) and (3.38), we have
[TABLE]
as due to (3.26). Also, weak* convergence in (3.34) implies that converges to [math] as . We plug (3.34) and (3.35) into (3.29), and get
[TABLE]
for each . This implies that solves
[TABLE]
Step 3. If for then, in addition to (3.27), we may choose satisfying
[TABLE]
From (3.2), we have
[TABLE]
Due to the lower semicontinuity of -norm with respect to the weak* convergence, we take in (3.43) and get
[TABLE]
which completes the proof.
4 Proof of Theorem 2
Reminding function spaces and defined in (1.19)–(1.20), we denote . Let be a positive number and we introduce , where
[TABLE]
For convenience, for we denote
[TABLE]
To construct solutions, we will use the method of iterations. Setting , and , we consider the following:
[TABLE]
[TABLE]
[TABLE]
Here for given we assume that and are non-negative and
[TABLE]
We note, due the maximum principle, that is uniformly bounded, i.e. . Now we are ready to present the proof of Theorem 2.
**Proof of Theorem 2 ** In case that is rather easy. From now on, we consider only the case that . For simplicity, we assume that (if not, we replace by , which doesn’t yield any crucial change for the local existence of solutions). Under the hypothesis that , we first show that for sufficiently small , which will be specified later.
First, recalling the equation (4.2) and using the estimate (1.18), in particular the case that , i.e. we obtain for all
[TABLE]
[TABLE]
We note, due to (2.9), that
[TABLE]
[TABLE]
[TABLE]
where we used (2.15) and . Thus, summing up the estimates, we have
[TABLE]
[TABLE]
Since , and , by taking a sufficiently small we obtain
[TABLE]
Next, we consider the equation (4.4). Let with with and with . We then define numbers and by and , respectively. We note that and . We then compute that
[TABLE]
[TABLE]
[TABLE]
Via maximal regularity (2.13) of the Stokes system and (4.8), we have for all
[TABLE]
[TABLE]
[TABLE]
[TABLE]
where we used that .
For the control of lower order derivative of , via potential estimate, we can also have
[TABLE]
[TABLE]
Thus, combining estimates (4.7), (4.9) and (4.10), and taking sufficiently small, we note that
[TABLE]
On the other hand, similarly as in (4.8), we note that
[TABLE]
[TABLE]
[TABLE]
[TABLE]
Using maximal regularity (2.12) for the equation (4.3) and the estimate (4.12), we have
[TABLE]
[TABLE]
[TABLE]
[TABLE]
where we used that and is the number defined in (4.1).
Since estimates of lower order derivative of can be obtained as in (4.10), we skip its details (from now on the estimate of lower order derivatives are omitted, unless it is necessary to be specified). Taking small enough such that
[TABLE]
the estimate (4.13) becomes
[TABLE]
which yields again for a sufficiently small
[TABLE]
Next, we show that this iteration gives a fixed point via contraction, which turns out to be unique solution of the system under considerations. Let , and . We then see that solves
[TABLE]
[TABLE]
[TABLE]
[TABLE]
where and . Here zero initial data are given, namely , and .
For convenience, we denote
[TABLE]
[TABLE]
Due to representation formula of the heat equation, we get
[TABLE]
Using the estimate of the heat equation, we note that
[TABLE]
We estimate separately. Indeed, for we obtain
[TABLE]
[TABLE]
where we used (2.14). Similarly, the second term can be estimated as follows:
[TABLE]
To compute , we introduce and we then obtain
[TABLE]
[TABLE]
[TABLE]
The term can be similarly estimated as , namely
[TABLE]
[TABLE]
[TABLE]
[TABLE]
Before we estimae , we let with . Choosing and with and , we have
[TABLE]
[TABLE]
[TABLE]
Using the estimate (4.18), we obtain
[TABLE]
[TABLE]
[TABLE]
Therefore, we obtain
[TABLE]
[TABLE]
Next, via maximal regularity of the Stokes system, we estimate as follows:
[TABLE]
[TABLE]
[TABLE]
[TABLE]
[TABLE]
Therefore,
[TABLE]
Next, we estimate .
[TABLE]
[TABLE]
[TABLE]
[TABLE]
[TABLE]
[TABLE]
[TABLE]
Taking sufficiently small, we obtain
[TABLE]
Summing up (4.19), (4.20) and (4.21) and noting that (4.19) holds for all , we have
[TABLE]
[TABLE]
[TABLE]
Taking sufficiently small, we obtain
[TABLE]
This yields fixed point via the theory of the contraction mapping. Once we prove (1.25) and (1.26), we complete the proof. Note that this can be done exactly the same as we did in the proof of Theorem 1.
Acknowledgements
Kyungkeun Kang’s work is supported by NRF-2019R1A2C1084685 and NRF-2015R1A5A1009350. Hwa Kil Kim’s work is supported by NRF-2021R1F1A1048231 and NRF-2018R1D1A1B07049357.
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