# Inter-residue, inter-protein and inter-family coevolution: bridging the scales

## TL;DR

This paper discusses how coevolution at various biological scales can be analyzed using data-driven computational methods, enabling integrated insights into protein interactions and evolution.

## Contribution

It introduces a unified statistical framework to study coevolution across multiple biological scales, connecting residue, protein, and family levels.

## Key findings

- Enormous sequence data enables new computational approaches.
- Potential for integrated structural and evolutionary insights.
- Framework bridges multiple coevolutionary scales.

## Abstract

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. While being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

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Source: https://tomesphere.com/paper/1906.09881