# Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia

## TL;DR

This study reveals how brain network dynamics during working memory are governed by control theory and dopamine receptor function, with alterations observed in schizophrenia, affecting state stability and transition energy landscapes.

## Contribution

It introduces a network control theory framework linking dopamine receptor gene expression to brain state stability and transitions during working memory, highlighting differences in schizophrenia.

## Key findings

- Working memory involves brainwide state switching.
- Dopamine D1 receptor expression correlates with state stability.
- Schizophrenia patients show altered network control properties.

## Abstract

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.

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Source: https://tomesphere.com/paper/1906.09290