# TempoCave: Visualizing Dynamic Connectome Datasets to Support Cognitive Behavioral Therapy

## TL;DR

TempoCave is a visualization tool designed to analyze dynamic brain networks from fMRI data, aiding clinical psychologists in understanding neurological disorders and treatment effects through interactive exploration of connectome datasets.

## Contribution

It introduces a novel visualization application that supports dynamic connectome analysis, tailored for clinical use in understanding brain activity related to mental health treatments.

## Key findings

- Analyzed pre- and post-treatment connectomes from 27 subjects.
- Provided new insights into the dynamic behavior of the human brain.
- Supported comparative analysis of brain network metrics.

## Abstract

We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of different regions in the brain. These patterns are calculated by processing raw data retrieved functional magnetic resonance imaging (fMRI) scans, which creates a network of weighted edges between each brain region, where the weight indicates how likely these regions are to activate synchronously. In particular, we support the analysis needs of clinical psychologists, who examine these modular affiliations and weighted edges and their temporal dynamics, utilizing them to understand relationships between neurological disorders and brain activity, which could have a significant impact on the way in which patients are diagnosed and treated. We summarize the core functionality of TempoCave, which supports a range of comparative tasks, and runs both in a desktop mode and in an immersive mode. Furthermore, we present a real-world use case that analyzes pre- and post-treatment connectome datasets from 27 subjects in a clinical study investigating the use of cognitive behavior therapy to treat major depression disorder, indicating that TempoCave can provide new insight into the dynamic behavior of the human brain.