# Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments

## TL;DR

This paper demonstrates the combined use of Magnetic Particle Imaging and navigation to track and steer superparamagnetic nanoparticles through bifurcations, enabling targeted drug delivery with high precision in flow experiments.

## Contribution

It introduces a method for quasi-simultaneous imaging and navigation of nanoparticles, analyzing their mobility and imaging performance in flow bifurcation experiments.

## Key findings

- Limiting flow velocity of 8.18 mL/s for particle flow through bifurcation
- Successful navigation of particles through stenosed bifurcation branches
- Potential for targeted drug delivery and improved therapy efficacy

## Abstract

Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL/s using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.