# Adaptive Tracking of Enzymatic Reactions with Quantum Light

## TL;DR

This paper demonstrates the use of quantum phase estimation to monitor enzyme activity in real-time with minimal invasiveness, advancing quantum sensing techniques for biological applications.

## Contribution

It introduces a novel quantum measurement approach for tracking enzymatic reactions, combining quantum physics methods with biological sensing.

## Key findings

- Quantum phase estimation enables real-time enzyme activity measurement.
- Quantum control reduces invasiveness and maintains sensitivity.
- Potential for developing highly sensitive quantum biosensors.

## Abstract

Enzymes are essential to maintain organisms alive. Some of the reactions they catalyze are associated with a change in reagents chirality, hence their activity can be tracked by using optical means. However, illumination affects enzyme activity: the challenge is to operate at low-intensity regime avoiding loss in sensitivity. Here we apply quantum phase estimation to real-time measurement of invertase enzymatic activity. Control of the probe at the quantum level demonstrates the potential for reducing invasiveness with optimized sensitivity at once. This preliminary effort, bringing together methods of quantum physics and biology, constitutes an important step towards full development of quantum sensors for biological systems.