# Fine-grained simulations of the microenvironment of vascularized tumours

## TL;DR

This paper introduces a computational tool for simulating the microenvironment of vascularized tumours, focusing on ecological and evolutionary dynamics that contribute to tumour heterogeneity and drug resistance.

## Contribution

The paper presents a novel computational simulation method to study tumour microenvironment ecology and its evolutionary processes.

## Key findings

- Tumour microenvironment acts as an ecological niche promoting heterogeneity.
- Evolutionary dynamics within the microenvironment influence drug resistance.
- Simulation results reveal how tumour clones adapt to ecological niches.

## Abstract

One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.