# Modelling of processes in nerve fibres at the interface of physiology and mathematics

## TL;DR

This paper develops a coupled mathematical model integrating electrical, mechanical, and thermal effects in nerve fibers, bridging physiology and physics to better understand nerve pulse propagation.

## Contribution

It introduces a novel coupled system of equations based on physical principles that models energy transduction and wave interactions in nerve fibers.

## Key findings

- The model generates combined electrical, mechanical, and thermal wave ensembles.
- It provides a framework for analyzing energy transduction in nerve fibers.
- The approach unifies physics, physiology, and mathematics in nerve modeling.

## Abstract

The in silico simulations are widely used in contemporary systems biology including the analysis of nerve pulse propagation. As known from numerous experiments, the propagation of an action potential is accompanied by mechanical and thermal effects. This calls for an analysis at the interface of physics, physiology and mathematics. In this paper, the background of the model equations governing the effects in nerve fibres is analysed from a physical viewpoint and then discussed how to unite them into a system by using the coupling forces. The leading hypothesis associates the coupling to the changes of variables, not to their values or amplitudes. This hypothesis models actually the physiological mechanisms of energy transductions in a fibre. The general assumptions in modelling the processes and the properties of the coupled system of equations are described. The dimensionless mathematical model which couples the action potential with mechanical waves together with temperature effects is presented in the Appendix. This model generates an ensemble of waves including the electrical signal and mechanical and thermal effects.