# Transient-evoked otoacoustic emission signals predicting outcomes of acute sensorineural hearing loss in patients with Meniere's Disease

## TL;DR

This study demonstrates that machine learning analysis of transient-evoked otoacoustic emission signals during acute Meniere's Disease episodes can predict hearing recovery with over 80% accuracy, offering a potential tool for prognosis.

## Contribution

The paper introduces a novel application of machine learning to analyze TEOAE signals for predicting hearing outcomes in MD patients, which was not previously established.

## Key findings

- Significant difference in 1-kHz group delay between outcome groups
- Support vector machine achieved >80% accuracy in prediction
- Baseline TEOAE parameters can inform prognosis during acute episodes

## Abstract

Background: Fluctuating hearing loss is characteristic of Meniere's Disease (MD) during acute episodes. However, no reliable audiometric hallmarks are available for counselling the hearing recovery possibility. Aims/Objectives: To find parameters for predicting MD hearing outcomes. Material and Methods: We applied machine learning techniques to analyse transient-evoked otoacoustic emission (TEOAE) signals recorded from patients with MD. Thirty unilateral MD patients were recruited prospectively after onset of acute cochleo-vestibular symptoms. Serial TEOAE and pure-tone audiogram (PTA) data were recorded longitudinally. Denoised TEOAE signals were projected onto the three most prominent principal directions through a linear transformation. Binary classification was performed using a support vector machine (SVM). TEOAE signal parameters, including signal energy and group delay, were compared between improved and nonimproved groups using Welchs t-test. Results: Signal energy did not differ (p = 0.64) but a significant difference in 1-kHz (p = 0.045) group delay was recorded between improved and nonimproved groups. The SVM achieved a cross-validated accuracy of >80% in predicting hearing outcomes. Conclusions and Significance: This study revealed that baseline TEOAE parameters obtained during acute MD episodes, when processed through machine learning technology, may provide information on outer hair cell function to predict hearing recovery.

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Source: https://tomesphere.com/paper/1905.13573