Optimal Rerandomization via a Criterion that Provides Insurance Against Failed Experiments
Adam Kapelner, Abba M. Krieger, Michael Sklar, David Azriel

TL;DR
This paper introduces an optimized rerandomization method for treatment-control experiments that balances observed covariate imbalance with the risk of unobserved covariate imbalance, improving experimental reliability.
Contribution
It proposes a new criterion for rerandomization that accounts for unobserved covariates and finds the optimal threshold to minimize estimator error.
Findings
Enhanced experimental power through optimized rerandomization.
Simulation and real data demonstrate improved design efficiency.
Open source R package available for implementation.
Abstract
We present an optimized rerandomization design procedure for a non-sequential treatment-control experiment. Randomized experiments are the gold standard for finding causal effects in nature. But sometimes random assignments result in unequal partitions of the treatment and control group visibly seen as imbalance in observed covariates. There can additionally be imbalance on unobserved covariates. Imbalance in either observed or unobserved covariates increases treatment effect estimator error inflating the width of confidence regions and reducing experimental power. "Rerandomization" is a strategy that omits poor imbalance assignments by limiting imbalance in the observed covariates to a prespecified threshold. However, limiting this threshold too much can increase the risk of contracting error from unobserved covariates. We introduce a criterion that combines observed imbalance while…
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Taxonomy
TopicsAdvanced Causal Inference Techniques · Statistical Methods and Inference · Statistical Methods in Clinical Trials
