# Mesoscopic simulations at the physics-chemistry-biology interface

## TL;DR

This paper reviews the Lattice Boltzmann-Particle Dynamics multiscale simulation approach for complex biological systems at the physics-chemistry-biology interface, highlighting current applications and future prospects in cellular and physiological modeling.

## Contribution

It introduces the LBPD multiscale paradigm and discusses its potential for simulating biological processes at physiological scales with future Exascale computing.

## Key findings

- Successful large-scale LBPD simulations of biopolymer translocation and amyloid aggregation.
- Potential for simulating cellular organization and organelles at physiological scales.
- Future applications in precision medicine and computational biology.

## Abstract

We discuss the Lattice Boltzmann-Particle Dynamics (LBPD) multiscale paradigm for the simulation of complex states of flowing matter at the interface between Physics, Chemistry and Biology. In particular, we describe current large-scale LBPD simulations of biopolymer translocation across cellular membranes, molecular transport in ion channels and amyloid aggregation in cells. We also provide prospects for future LBPD explorations in the direction of cellular organization, the direct simulation of full biological organelles, all the way to up to physiological scales of potential relevance to future precision-medicine applications, such as the accurate description of homeostatic processes. It is argued that, with the advent of Exascale computing, the mesoscale physics approach advocated in this paper, may come to age in the next decade and open up new exciting perspectives for physics-based computational medicine.