Graph-Based Method for Anomaly Prediction in Brain Network

TL;DR

This paper introduces a novel graph auto-encoder framework with hypersphere distribution for analyzing complex brain networks in rs-fMRI data, aiding in anomaly detection and understanding brain plasticity.

Contribution

It proposes a high-order graph auto-encoder with hypersphere distribution for non-Euclidean brain data analysis, enhancing anomaly detection in brain networks.

Findings

Identified abnormal brain connection patterns.

Correlated affected regions over time.

Demonstrated potential for brain disease diagnosis.

Abstract

Resting-state functional MRI (rs-fMRI) in functional neuroimaging techniques have improved in brain disorders, dysfunction studies via mapping the topology of the brain connections, i.e. connectopic mapping. Since, there are the slight differences between healthy and unhealthy brain regions and functions, investigation into the complex topology of functional and structural brain networks in human is a complicated task with the growth of evaluation criteria. Irregular graph deep learning applications have widely spread to understanding human cognitive functions that are linked to gene expression and related distributed spatial patterns, because the neuronal networks of the brain can hold dynamically a variety of brain solutions with different activity patterns and functional connectivity, these applications might also be involved with both node-centric and graph-centric tasks. In this paper, we performed a novel approach of individual generative model and high order graph analysis for the region of interest recognition areas of the brain which do not have a normal connection during applying certain tasks. Here, we proposed a high order framework of Graph Auto-Encoder (GAE) with a hypersphere distributer for functional data analysis in brain imaging studies that is underlying non-Euclidean structure in the learning of strong non-rigid graphs among large scale data. In addition, we distinguished the possible modes of correlations in abnormal brain connections. Our finding will show the degree of correlation between the affected regions and their simultaneous occurrence over time that can be used to diagnose brain diseases or revealing the ability of the nervous system to modify in brain topology at all angles, brain plasticity, according to input stimuli.