Phytochemical study and evaluation of the cytotoxic properties of methanolic extract from Baccharis obtusifolia

TL;DR

This study investigates the cytotoxic effects of Baccharis obtusifolia methanolic extract on various cancer cell lines, identifying specific flavonoids responsible for its activity.

Contribution

It is the first to evaluate the cytotoxic activity of B. obtusifolia extract and isolate active flavonoid compounds with potential biomedical applications.

Findings

Significant cytotoxicity in colon and astrocytoma cancer cell lines.

Isolation of two flavonoid compounds from the extract.

Identification of flavonoids with potential anticancer properties.

Abstract

Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extract displayed the largest substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral astrocytoma (D-384). Chromatographic purification of the B. obtusifolia methanolic extract led to the isolation and identification of 5,4'-dihydroxy-7-methoxyflavone (1) and 5-hydroxy-7,4'-dimethoxyflavone (2) compounds of the flavonoid type.