# Melting of DNA in confined geometry

## TL;DR

This paper investigates how the geometry and confinement affect the thermal stability and melting behavior of DNA molecules of various lengths using a statistical model.

## Contribution

It introduces a comparative analysis of DNA melting in conical and cylindrical confined geometries, highlighting the impact of geometry on stability.

## Key findings

- Confinement influences DNA melting temperature.
- Geometry significantly affects DNA opening mechanisms.
- DNA stability varies with confined space shape.

## Abstract

The stability of DNA molecule during the encapsulation process is a topic of intense research. We study the thermal stability of the double-stranded DNA molecule of different lengths in a confined space. Using a statistical model we evaluate the melting profile of DNA of different length in two geometries: conical and cylindrical. Our results show that not only the confinement but also the geometry of the confined space plays a prominent role in the stability and opening manner of the molecule.