# Interfacing Graphene-Based Materials With Neural Cells

## TL;DR

This review discusses the use of graphene-based materials in neuroscience, focusing on their applications in drug delivery, tissue engineering, neural growth, and the importance of modeling their interactions with biological systems.

## Contribution

It provides a comprehensive overview of recent advances, challenges, and future directions in interfacing graphene materials with neural cells, including theoretical modeling and biomedical applications.

## Key findings

- Graphene materials can be used as neural tissue scaffolds.
- Functionalized graphene can cross the blood-brain barrier.
- Graphene influences neural cell excitability through charge transfer.

## Abstract

The scientific community has witnessed an exponential increase in the applications of graphene and graphene-based materials in a wide range of fields. For what concerns neuroscience, the interest raised by these materials is two-fold. On one side, nanosheets made of graphene or graphene derivatives (graphene oxide, or its reduced form) can be used as carriers for drug delivery. Here, an important aspect is to evaluate their toxicity, which strongly depends on flake composition, chemical functionalization and dimensions. On the other side, graphene can be exploited as a substrate for tissue engineering. In this case, conductivity is probably the most relevant amongst the various properties of the different graphene materials, as it may allow to instruct and interrogate neural networks, as well as to drive neural growth and differentiation. In this review, we try to give a comprehensive view of the accomplishments and new challenges of the field, as well as which in our view are the most exciting directions to take in the immediate future. These include the need to engineer multifunctional nanoparticles able to cross the blood-brain-barrier to reach neural cells, and to achieve on-demand delivery of specific drugs. We describe the state-of-the-art in the use of graphene materials to engineer three-dimensional scaffolds to drive neuronal growth and regeneration in vivo, and the possibility of using graphene as a component of hybrid composites/multi-layer organic electronics devices. Last but not least, we address the need of an accurate theoretical modeling of the interface between graphene and biological material, by modeling the interaction of graphene with proteins and cell membranes at the nanoscale, and describing the physical mechanism(s) of charge transfer by which the various graphene materials can influence the excitability and physiology of neural cells.

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Source: https://tomesphere.com/paper/1903.08440