# Global Perturbation of Initial Geometry in a Biomechanical Model of Cortical Morphogenesis

## TL;DR

This paper investigates how variations in initial brain geometry influence cortical folding patterns using biomechanical simulations with an adaptive spherical parameterization approach.

## Contribution

It introduces a novel simulation method to analyze the impact of initial geometry on cortical folding, highlighting its role as a key factor in pattern formation.

## Key findings

- Initial geometry significantly affects folding patterns
- Adaptive spherical parameterization enables detailed analysis
- Simulation results support biological hypotheses

## Abstract

Cortical folding pattern is a main characteristic of the geometry of the human brain which is formed by gyri (ridges) and sulci (grooves). Several biological hypotheses have suggested different mechanisms that attempt to explain the development of cortical folding and its abnormal evolutions. Based on these hypotheses, biomechanical models of cortical folding have been proposed. In this work, we compare biomechanical simulations for several initial conditions by using an adaptive spherical parameterization approach. Our approach allows us to study and explore one of the most potential sources of reproducible cortical folding pattern: the specification of initial geometry of the brain.