# Accurate and robust segmentation of neuroanatomy in T1-weighted MRI by combining spatial priors with deep convolutional neural networks

## TL;DR

This paper presents a new deep learning-based method for accurate, robust, and fast neuroanatomical segmentation in T1-weighted MRI, combining spatial priors with data augmentation to outperform existing techniques.

## Contribution

The authors introduce a novel 3D convolutional neural network approach that integrates spatial priors and elastic deformation augmentation, achieving state-of-the-art accuracy with high efficiency.

## Key findings

- Achieved high Dice coefficients in hippocampus and sub-cortical segmentation.
- Demonstrated robustness comparable to manual expert segmentation.
- Significantly faster than traditional multi-atlas methods.

## Abstract

Neuroanatomical segmentation in magnetic resonance imaging (MRI) of the brain is a prerequisite for volume, thickness and shape measurements. This work introduces a new highly accurate and versatile method based on 3D convolutional neural networks for the automatic segmentation of neuroanatomy in T1-weighted MRI. In combination with a deep 3D fully convolutional architecture, efficient linear registration-derived spatial priors are used to incorporate additional spatial context into the network. An aggressive data augmentation scheme using random elastic deformations is also used to regularize the networks, allowing for excellent performance even in cases where only limited labelled training data are available. Applied to hippocampus segmentation in an elderly population (mean Dice coefficient = 92.1%) and sub-cortical segmentation in a healthy adult population (mean Dice coefficient = 89.5%), we demonstrate new state-of-the-art accuracies and a high robustness to outliers with the same architecture. Further validation on a multi-structure segmentation task in a scan-rescan dataset demonstrates accuracy (mean Dice coefficient = 86.6%) similar to the scan-rescan reliability of expert manual segmentations (mean Dice coefficient = 86.9%), and improved reliability compared to both expert manual segmentations and automated segmentations using FIRST. Furthermore, our method maintains a highly competitive runtime performance (e.g. requiring only 10 seconds for left/right hippocampal segmentation in 1x1x1 MNI stereotaxic space), orders of magnitude faster than conventional multi-atlas segmentation methods.