# Veridical Data Science

## TL;DR

The paper introduces the PCS framework for veridical data science, emphasizing predictability, computability, and stability to ensure responsible, reliable, and transparent data analysis across the entire lifecycle.

## Contribution

It proposes a comprehensive workflow and documentation approach incorporating stability principles, along with new inference procedures like PCS perturbation intervals and hypothesis testing.

## Key findings

- PCS inference performs well in high-dimensional, sparse models.
- The framework enhances reproducibility with PCS documentation tools.
- Illustrated through neuroscience and genomics case studies.

## Abstract

Building and expanding on principles of statistics, machine learning, and scientific inquiry, we propose the predictability, computability, and stability (PCS) framework for veridical data science. Our framework, comprised of both a workflow and documentation, aims to provide responsible, reliable, reproducible, and transparent results across the entire data science life cycle. The PCS workflow uses predictability as a reality check and considers the importance of computation in data collection/storage and algorithm design. It augments predictability and computability with an overarching stability principle for the data science life cycle. Stability expands on statistical uncertainty considerations to assess how human judgment calls impact data results through data and model/algorithm perturbations. Moreover, we develop inference procedures that build on PCS, namely PCS perturbation intervals and PCS hypothesis testing, to investigate the stability of data results relative to problem formulation, data cleaning, modeling decisions, and interpretations. We illustrate PCS inference through neuroscience and genomics projects of our own and others and compare it to existing methods in high dimensional, sparse linear model simulations. Over a wide range of misspecified simulation models, PCS inference demonstrates favorable performance in terms of ROC curves. Finally, we propose PCS documentation based on R Markdown or Jupyter Notebook, with publicly available, reproducible codes and narratives to back up human choices made throughout an analysis. The PCS workflow and documentation are demonstrated in a genomics case study available on Zenodo.