Nanopore fabrication via tip-controlled local breakdown using an atomic force microscope

TL;DR

This paper introduces a tip-controlled dielectric breakdown method using an atomic force microscope to rapidly and precisely fabricate nanopores in membranes, significantly improving speed and scalability over traditional techniques.

Contribution

The study presents a novel, fast, and scalable approach for nanopore fabrication with nanometer precision using a conductive AFM tip for dielectric breakdown.

Findings

Pores are formed at the tip position with high precision.

Fabrication time is reduced to approximately 10 ms per pore.

Over 300 pores can be fabricated in half an hour on a single membrane.

Abstract

The dielectric breakdown approach for forming nanopores has greatly accelerated the pace of research in solid-state nanopore sensing, enabling inexpensive formation of nanopores via a bench top setup. Here we demonstrate the potential of tip controlled dielectric breakdown (TCLB) to fabricate pores 100$\times$ faster, with high scalability and nanometre positioning precision. A conductive atomic force microscope (AFM) tip is brought into contact with a nitride membrane positioned above an electrolyte reservoir. Application of a voltage pulse at the tip leads to the formation of a single nanoscale pore. Pores are formed precisely at the tip position with a complete suppression of multiple pore formation. In addition, our approach greatly accelerates the electric breakdown process, leading to an average pore fabrication time on the order of 10 ms, at least 2 orders of magnitude shorter than achieved by classic dielectric breakdown approaches. With this fast pore writing speed we can fabricate over 300 pores in half an hour on the same membrane.