Determining Multifunctional Genes and Diseases in Human Using Gene Ontology

TL;DR

This paper explores the relationship between multifunctional genes and diseases using Gene Ontology annotations, aiming to enhance understanding for healthcare and drug discovery.

Contribution

It introduces a novel approach to analyze gene-disease relationships based on multifunctionality derived from Gene Ontology data.

Findings

Identified key multifunctional genes associated with multiple diseases

Demonstrated the utility of Gene Ontology in gene-disease relationship analysis

Provided insights into gene functions relevant to disease mechanisms

Abstract

The study of human genes and diseases is very rewarding and can lead to improvements in healthcare, disease diagnostics and drug discovery. In this paper, we further our previous study on gene disease relationship specifically with the multifunctional genes. We investigate the multifunctional gene disease relationship based on the published molecular function annotations of genes from the Gene Ontology which is the most comprehensive source on gene functions.