Hopf-bifurcation analysis of pneumococcal pneumonia with time delays

TL;DR

This paper models pneumococcal pneumonia dynamics incorporating time delays, analyzing stability and bifurcations, and demonstrating how delays influence disease persistence and oscillations.

Contribution

It introduces a novel delay differential equation model for pneumococcal pneumonia and analyzes the effects of delays on stability and Hopf-bifurcation phenomena.

Findings

Disease-free equilibrium is stable if R0<1

Endemic equilibrium stability depends on delays

Delays can induce oscillations and bifurcations

Abstract

In this paper, a mathematical model of pneumococcal pneumonia with time delays is proposed. The stability theory of delay differential equations is used to analyze the model. The results show that the disease-free equilibrium is asymptotically stable if the control reproduction ratio R0 is less than unity and unstable otherwise. The stability of equilibria with delays shows that the endemic equilibrium is locally stable without delays and stable if the delays are under conditions. The existence of Hopf-bifurcation is investigated and transversality conditions proved. The model results suggest that as the respective delays exceed some critical value past the endemic equilibrium, the system loses stability through the process of local birth or death of oscillations. Further, a decrease or an increase in the delays leads to asymptotic stability or instability of the endemic equilibrium respectively. The analytical results, are supported by numerical simulations. Keywords: Time delay, Pneumococcal pneumonia, Vaccination, Stability, Hopf-bifurcation