# Dynamics of growth and form in prebiotic vesicles

## TL;DR

This paper presents a minimal model for prebiotic vesicle dynamics, capturing their growth, shape, and division, which may shed light on the origins of cellular life and guide synthetic vesicle creation.

## Contribution

The study introduces a coupled model of membrane growth, deformation, and permeation, revealing how simple physicochemical parameters influence vesicle morphology and dynamics.

## Key findings

- Model reproduces diverse vesicle shapes observed in prebiotic conditions
- Simulations suggest parameters controlling growth and permeability dictate morphology
- Provides guidelines for synthesizing complex vesicle shapes from simple components

## Abstract

The growth, form, and division of prebiotic vesicles, membraneous bags of fluid of varying components and shapes is hypothesized to have served as the substrate for the origin of life. The dynamics of these out-of-equilibrium structures is controlled by physicochemical processes that include the intercalation of amphiphiles into the membrane, fluid flow across the membrane, and elastic deformations of the membrane. To understand prebiotic vesicular forms and their dynamics, we construct a minimal model that couples membrane growth, deformation, and fluid permeation, ultimately couched in terms of two dimensionless parameters that characterize the relative rate of membrane growth and the membrane permeability. Numerical simulations show that our model captures the morphological diversity seen in extant precursor mimics of cellular life, and might provide simple guidelines for the synthesis of these complex shapes from simple ingredients.