# A novel approach to medical radioisotope production using inverse kinematics: a successful production test of the theranostic radionuclide 67Cu

## TL;DR

This paper introduces a new inverse kinematics method for producing medical radioisotopes, demonstrating a successful test for 67Cu production, which could improve isotope yields for medical applications.

## Contribution

The study presents the first successful proof-of-concept of producing 67Cu via inverse kinematics using a heavy-ion beam and hydrogen target, highlighting potential for enhanced isotope production.

## Key findings

- Successful production of 67Cu using inverse kinematics
- Identification of co-produced isotopes and radioimpurities
- Potential for producing additional radioisotopes with secondary targets

## Abstract

A novel method for the production of important medical radioisotopes has been developed. The approach is based on performing the nuclear reaction in inverse kinematics, namely sending a heavy-ion beam of appropriate energy on a light target (e.g. H, d, He) and collecting the isotope of interest. In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67Cu (T 1/2 =62 h) via the reaction of a 70Zn beam at 15 MeV/nucleon with a hydrogen gas target. The 67Cu radionuclide, alongside other coproduced isotopes, was collected after the gas target on an Al catcher foil and their radioactivity was measured by off-line {\gamma}-ray analysis. After 36 h from the end of the irradiation, apart from the product of interest 67Cu, the main radioimpurity coming from the 70Zn+p reaction was 69mZn (T 1/2 =13.8 h) that can be reduced by further radio-cooling. Moreover, along with the radionuclide of interest produced in inverse kinematics, the production of additional radioisotopes is possible by making use of the forward-focused neutrons from the reaction and letting them interact with a secondary target. A preliminary successful test of this concept was realized in the present study. The main requirement to obtain activities appropriate for preclinical studies is the development of high-intensity heavy-ion primary beams.