# Theoretical modeling of polymer translocation: From the electrohydrodynamics of short polymers to the fluctuating long polymers

## TL;DR

This paper reviews theoretical models of polymer translocation through nanopores, focusing on short polymers with electrohydrodynamic forces and long polymers with tension propagation, highlighting recent advances and analytical results.

## Contribution

It introduces a comprehensive review of models for both short and long polymer translocation, including electrohydrodynamics and iso-flux tension propagation theories, with new analytical insights.

## Key findings

- Electrohydrodynamic theory accurately predicts translocation velocity dependence on pressure.
- Electrostatic mechanisms explain DNA mobility inversion and salt effects in nanopores.
- Iso-flux tension propagation theory provides exact scaling laws for translocation time.

## Abstract

The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer fluctuations. In this review, we discuss the modeling of polymer translocation in the distinct regimes of short and long polymers where these two effects decouple. For the case of short polymers where polymer fluctuations are negligible, we present a stiff polymer model including the details of the electrohydrodynamic forces on the translocating molecule. We first show that the electrohydrodynamic theory can accurately characterize the hydrostatic pressure dependence of the polymer translocation velocity and time in pressure-voltage-driven polymer trapping experiments. Then, we discuss the electrostatic correlation mechanisms responsible for the experimentally observed DNA mobility inversion by added multivalent cations in solid-state pores, and the rapid growth of polymer capture rates by added monovalent salt in $\alpha$-Hemolysin pores. In the opposite regime of long polymers where polymer fluctuations prevail, we review the iso-flux tension propagation (IFTP) theory which can characterize the translocation dynamics at the level of single segments. The IFTP theory is valid for a variety of polymer translocation and pulling scenarios. We discuss the predictions of the theory for fully flexible and rodlike pore-driven and end-pulled translocation scenarios, where exact analytic results can be derived for the scaling of the translocation time with chain length and driving force.