# Bridging trees for posterior inference on Ancestral Recombination Graphs

**Authors:** Kari Heine, Alex Beskos, Ajay Jasra, David Balding, Maria, De Iorio

arXiv: 1812.01345 · 2019-03-06

## TL;DR

This paper introduces Arbores, a novel MCMC algorithm with a bridging technique that enables efficient, parallelizable inference of ancestral recombination graphs from DNA sequences.

## Contribution

It presents a new bridging procedure for MCMC inference of ancestral recombination graphs, allowing large-scale parallel computations.

## Key findings

- Enables scalable inference of ancestral recombination graphs.
- Facilitates parallel processing of local computations.
- Improves efficiency over previous methods.

## Abstract

We present a new Markov chain Monte Carlo algorithm, implemented in software Arbores, for inferring the history of a sample of DNA sequences. Our principal innovation is a bridging procedure, previously applied only for simple stochastic processes, in which the local computations within a bridge can proceed independently of the rest of the DNA sequence, facilitating large-scale parallelisation.

## Full text

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## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/1812.01345/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/1812.01345/full.md

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Source: https://tomesphere.com/paper/1812.01345