TIFTI: A Framework for Extracting Drug Intervals from Longitudinal Clinic Notes

TL;DR

TIFTI is a framework designed to extract detailed oral drug treatment intervals from unstructured clinical notes, combining temporal information from text and timestamps to improve treatment history understanding.

Contribution

This work introduces TIFTI, a novel framework that integrates document-level sequence labeling and date extraction for treatment interval inference from unstructured notes.

Findings

Exact start date matching in 46% of cases within 30 days

Exact end date matching in 52% of cases within 30 days

Model generalizes well across different cancer types without retraining

Abstract

Oral drugs are becoming increasingly common in oncology care. In contrast to intravenous chemotherapy, which is administered in the clinic and carefully tracked via structure electronic health records (EHRs), oral drug treatment is self-administered and therefore not tracked as well. Often, the details of oral cancer treatment occur only in unstructured clinic notes. Extracting this information is critical to understanding a patient's treatment history. Yet, this a challenging task because treatment intervals must be inferred longitudinally from both explicit mentions in the text as well as from document timestamps. In this work, we present TIFTI (Temporally Integrated Framework for Treatment Intervals), a robust framework for extracting oral drug treatment intervals from a patient's unstructured notes. TIFTI leverages distinct sources of temporal information by breaking the problem down into two separate subtasks: document-level sequence labeling and date extraction. On a labeled dataset of metastatic renal-cell carcinoma (RCC) patients, it exactly matched the labeled start date in 46% of the examples (86% of the examples within 30 days), and it exactly matched the labeled end date in 52% of the examples (78% of the examples within 30 days). Without retraining, the model achieved a similar level of performance on a labeled dataset of advanced non-small-cell lung cancer (NSCLC) patients.