Kinetic Membrane Model of Outer Hair Cells I: Motile Elements with Two Conformational States

TL;DR

This paper develops a kinetic membrane model for outer hair cells, incorporating conformational states and turgor pressure effects, to better understand their role in auditory amplification.

Contribution

It extends previous 1D models by using a membrane-based kinetic theory to analyze OHC electromechanical coupling with more realistic assumptions.

Findings

Elastic load shifts voltage dependence of membrane capacitance.

Turgor pressure influences power output in systems with inertia.

Maximal power output remains around 10 fW, consistent with prior models.

Abstract

The effectiveness of outer hair cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian hearing, depends on the mechanical power output of these cells. Electromechanical coupling in OHCs, which enables these cells to convert electrical energy into mechanical energy, has been analyzed in detail using isolated cells using primarily static membrane models. In the preceding reports, mechanical output of OHC was evaluated by developing a kinetic theory based on a simplified one-dimensional (1D) model for OHCs. Here such a kinetic description of OHCs is extended by using the membrane model, which has been used for analyzing in vitro experiments. The present theory predicts, for systems without inertial load, that elastic load enhances positive shift of voltage dependence of the membrane capacitance due to turgor pressure. For systems with inertia, mechanical power output also depends on turgor pressure. The maximal power output is, however, similar to the previous prediction of up to ~10 fW based on the 1D model.