Modes of rapid polygenic adaptation

TL;DR

This paper explores two modes of rapid polygenic adaptation, integrating population and quantitative genetics, and discusses how to detect these processes genomically, highlighting the potential for swift evolutionary changes.

Contribution

It provides a theoretical framework linking selective sweeps and subtle allele frequency shifts in polygenic adaptation, bridging population and quantitative genetics.

Findings

Polygenic adaptation can be rapid, involving either large or small allele frequency changes.

The size of phenotypic effects influences whether adaptation is dramatic or subtle.

Methods for detecting selective sweeps are well-developed, but tools for small shifts are still emerging.

Abstract

Many experimental and field studies have shown that adaptation can occur very rapidly. Two qualitatively different modes of fast adaptation have been proposed: selective sweeps wherein large shifts in the allele frequencies occur at a few loci and evolution via small changes in the allele frequencies at many loci. While the first process has been thoroughly investigated within the framework of population genetics, the latter is based on quantitative genetics and is much less understood. Here we summarize results from our recent theoretical studies of a quantitative genetic model of polygenic adaptation that makes explicit reference to population genetics to bridge the gap between the two frameworks. Our key results are that polygenic adaptation may be a rapid process and can proceed via subtle or dramatic changes in the allele frequency depending on the sizes of the phenotypic effects relative to a threshold value. We also discuss how the signals of polygenic selection may be detected in the genome. While powerful methods are available to identify signatures of selective sweeps at loci controling quantitative traits, the development of statistical tests for detecting small shifts of allele frequencies at quantitative trait loci is still in its infancy.