Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model

TL;DR

This paper extends a cell motility model to include forces from cell-cell collision and adhesion, analyzing their effects on cell migration and shape, with applications to cancer cell behavior.

Contribution

The paper introduces new components into the existing lamellipodium model to simulate cell-cell interactions, providing insights into their influence on cell dynamics.

Findings

Cell-cell collision and adhesion significantly affect cell migration.

Simulated cells show morphological similarities to HeLa cancer cells.

The extended model captures key physical and biological forces in cell interactions.

Abstract

We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.