Extraction of SSVEPs-based Inherent Fuzzy Entropy Using a Wearable Headband EEG in Migraine Patients

TL;DR

This study introduces a wearable EEG-based method using inherent fuzzy entropy to distinguish migraine phases, demonstrating its potential for pre-ictal alerting with high classification accuracy.

Contribution

It applies multi-scale inherent fuzzy entropy to SSVEP EEG data from a wearable device, revealing phase-specific entropy changes and achieving effective migraine phase classification.

Findings

EEG entropy increases with stimulus in healthy and inter-ictal patients

Pre-ictal phase shows decreased entropy compared to inter-ictal phase

Classification model achieves 81% accuracy distinguishing migraine phases

Abstract

Inherent fuzzy entropy is an objective measurement of electroencephalography (EEG) complexity, reflecting the robustness of brain systems. In this study, we present a novel application of multi-scale relative inherent fuzzy entropy using repetitive steady-state visual evoked potentials (SSVEPs) to investigate EEG complexity change between two migraine phases, i.e. inter-ictal (baseline) and pre-ictal (before migraine attacks) phases. We used a wearable headband EEG device with O1, Oz, O2 and Fpz electrodes to collect EEG signals from 80 participants (40 migraine patients and 40 healthy controls [HCs]) under the following two conditions: during resting state and SSVEPs with five 15-Hz photic stimuli. We found a significant enhancement in occipital EEG entropy with increasing stimulus times in both HCs and patients in the inter-ictal phase but a reverse trend in patients in the pre-ictal phase. In the 1st SSVEP , occipital EEG entropy of the HCs was significantly higher than that of patents in the pre-ictal phase (FDR-adjusted p < 0.05). Regarding the transitional variance of EEG entropy between the 1st and 5th SSVEPs, patients in the pre-ictal phase exhibited significantly lower values than patients in the inter-ictal phase (FDR-adjusted p < 0.05). Furthermore, in the classification model, the AdaBoost ensemble learning showed an accuracy of 81% and AUC of 0.87 for classifying inter-ictal and pre-ictal phases. In contrast, there were no differences in EEG entropy among groups or sessions by using other competing entropy models, including approximate entropy, sample entropy and fuzzy entropy on the same dataset. In conclusion, inherent fuzzy entropy offers novel applications in visual stimulus environments and may have the potential to provide a pre-ictal alert to migraine patients.