Diffusive MIMO Molecular Communications: Channel Estimation, Equalization and Detection
S. M. Reza Rouzegar, Umberto Spagnolini

TL;DR
This paper explores channel estimation and equalization techniques for diffusive MIMO molecular communication systems, addressing inter-symbol and inter-link interference to improve data rates and reliability.
Contribution
It introduces training-based channel estimation methods, designs optimal training sequences, and evaluates equalization strategies specifically for diffusive MIMO molecular communication.
Findings
Maximum likelihood and least-squares estimators effectively estimate the channel.
Decision feedback equalizer structures mitigate ISI and ILI.
Time interleaving significantly reduces inter-link interference.
Abstract
In diffusion-based communication, as for molecular systems, the achievable data rate is low due to the stochastic nature of diffusion which exhibits a severe inter-symbol-interference (ISI). Multiple-Input Multiple-Output (MIMO) multiplexing improves the data rate at the expense of an inter-link interference (ILI). This paper investigates training-based channel estimation schemes for diffusive MIMO (D-MIMO) systems and corresponding equalization methods. Maximum likelihood and least-squares estimators of mean channel are derived, and the training sequence is designed to minimize the mean square error (MSE). Numerical validations in terms of MSE are compared with Cramer-Rao bound derived herein. Equalization is based on decision feedback equalizer (DFE) structure as this is effective in mitigating diffusive ISI/ILI. Zero-forcing, minimum MSE and least-squares criteria have been paired to…
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