Sorting and separation of microparticles by surface properties using liquid crystal-enabled electro-osmosis

TL;DR

This paper introduces a novel liquid crystal-enabled electro-osmosis technique for sorting and separating microparticles based on subtle surface properties, surpassing traditional bulk property-based methods.

Contribution

The work presents a new method using nematic liquid crystals and electric fields to differentiate particles with identical bulk properties but different surface features.

Findings

Successfully separated particles based on surface properties

Demonstrated sorting in a liquid crystal medium

Potential applications in bio-sensing and lab-on-a-chip

Abstract

Sorting and separation of microparticles is a challenging problem of interdisciplinary nature. Existing technologies can differentiate microparticles by their bulk properties, such as size, density, electric polarizability, etc. The next level of challenge is to separate particles that show identical bulk properties and differ only in subtle surface features, such as functionalization with ligands. In this work, we propose a technique to sort and separate particles and fluid droplets that differ in surface properties. As a dispersive medium, we use a nematic liquid crystal (LC) rather than an isotropic fluid, which allows us to amplify the difference in surface properties through distinct perturbations of LC order around the dispersed particles. The particles are placed in a LC cell with spatially distorted molecular orientation subject to an alternating current electric field. The gradients of the molecular orientation perform two functions. First, elastic interactions between these pre-imposed gradients and distortions around the particles separate the particles with different surface properties in space. Second, these pre-imposed patterns create electro-osmotic flows powered by the electric field that transport the sorted particles to different locations thus separating them. The demonstrated unique sorting and separation capability opens opportunities in lab-on-a-chip, cell sorting and bio-sensing applications.