Monitoring hemolysis continuously in real time

TL;DR

This paper introduces a straightforward method for real-time, continuous monitoring of hemolysis during clinical procedures by measuring blood conductivity changes caused by red blood cell rupture.

Contribution

It presents a novel, simple resistance measurement technique to accurately detect small changes in hemolysis levels in blood.

Findings

Small hemolysis changes detected via resistance measurement

Method effective in porcine blood samples

Potential for real-time clinical monitoring

Abstract

Blood damage (hemolysis) can occur during clinical procedures, e.g. dialysis, due to human error or faulty equipment, and it can cause significant harm to the patient or even death. We propose a simple technique to monitor changes in hemolysis levels accurately, continuously, and in real time. As red blood cells rupture, the overall conductivity of the blood increases. Here, we demonstrate that small changes in porcine blood hemolysis can be detected accurately through a simple resistance measurement.