Spontaneous and Directed Symmetry Breaking in the Formation of Chiral Nanocrystals

TL;DR

This study demonstrates spontaneous and directed symmetry breaking in the formation of chiral nanocrystals, revealing mechanisms for chiral amplification relevant to the origin of biological homochirality.

Contribution

It provides a quantitative framework for understanding chiral amplification via symmetry breaking and external chiral influences in nanocrystal synthesis.

Findings

Strong chiral amplification observed in nanocrystal synthesis

Chiral tartaric acid directs nanocrystal handedness

Critical temperature governs symmetry breaking transition

Abstract

The homochirality of biomolecules remains one of the outstanding puzzles concerning the beginning of life. Chiral amplification of a randomly perturbed racemic mixture of chiral molecules is a well-accepted prerequisite for all routes to biological homochirality. Some models have suggested that such amplification occurred due to asymmetric discrimination of chiral biotic or prebiotic molecules when they adsorbed onto crystalline surfaces. While chiral amplification has been demonstrated on surfaces of both chiral and achiral crystals, the mechanism that would produce an enantiomeric imbalance in the chiral surfaces themselves has not been addressed. Here we report strong chiral amplification in the colloidal synthesis of intrinsically chiral lanthanide phosphate nanocrystals, quantitatively measured via the circularly polarized luminescence of the lanthanide ions within the nanocrystals. The amplification involves spontaneous symmetry breaking into either left- or right-handed nanocrystals below a critical temperature. Furthermore, chiral tartaric acid molecules in the solution act as an external chiral field, sensitively directing the amplified nanocrystal handedness through a discontinuous transition between left- and right-handed excess. These characteristics suggest a conceptual framework for chiral amplification, based on the statistical thermodynamics of critical phenomena, which we use to quantitatively account for the observations. Our results demonstrate how chiral minerals with high enantiomeric excess could have grown locally in a primordial racemic aqueous environment.