Adhesion dynamics of confined membranes

TL;DR

This paper models the complex dynamics of confined lipid membranes, revealing three distinct regimes of behavior based on membrane area, including flat, coarsening, and labyrinthine wrinkle patterns, with implications for understanding membrane adhesion.

Contribution

The study introduces a novel thin film model for inextensible membranes with bending rigidity confined between adhesive walls, incorporating a nonlocal tension term and analyzing different dynamical regimes.

Findings

Regime A: membranes form flat adhesion domains and freeze.

Regime B: membranes exhibit endless coarsening with coexistence of flat and wrinkle domains.

Regime C: membranes are covered by a frozen labyrinthine wrinkle pattern.

Abstract

We report on the modeling of the dynamics of confined lipid membranes. We derive a thin film model in the lubrication limit which describes an inextensible liquid membrane with bending rigidity confined between two adhesive walls. The resulting equations share similarities with the Swift-Hohenberg model. However, inextensibility is enforced by a time-dependent nonlocal tension. Depending on the excess membrane area available in the system, three different dynamical regimes, denoted as A, B and C, are found from the numerical solution of the model. In regime A, membranes with small excess area form flat adhesion domains and freeze. Such freezing is interpreted by means of an effective model for curvature-driven domain wall motion. The nonlocal membrane tension tends to a negative value corresponding to the linear stability threshold of flat domain walls in the Swift-Hohenberg equation. In regime B, membranes with intermediate excess areas exhibit endless coarsening with coexistence of flat adhesion domains and wrinkle domains. The tension tends to the nonlinear stability threshold of flat domain walls in the Swift-Hohenberg equation. The fraction of the system covered by the wrinkle phase increases linearly with the excess area in regime B. In regime C, membranes with large excess area are completely covered by a frozen labyrinthine pattern of wrinkles. As the excess area is increased, the tension increases and the wavelength of the wrinkles decreases. For large membrane area, there is a crossover to a regime where the extrema of the wrinkles are in contact with the walls. In all regimes after an initial transient, robust localised structures form, leading to an exact conservation of the number of adhesion domains.