Solvability of a Keller-Segel system with signal-dependent sensitivity and essentially sublinear production
Giuseppe Viglialoro, Thomas E. Woolley

TL;DR
This paper proves the global existence and boundedness of solutions for a chemotaxis system with signal-dependent sensitivity and sublinear production, ensuring no cell collapse occurs in a bounded domain.
Contribution
It establishes the solvability and boundedness of solutions for a Keller-Segel chemotaxis system with general sensitivity and sublinear chemical production, extending previous results.
Findings
No chemotactic collapse occurs for the cell distribution.
Global and uniformly bounded solutions exist for all initial data.
Numerical simulations illustrate diverse dynamics of the system.
Abstract
In this paper we consider the zero-flux chemotaxis-system \begin{equation*} \begin{cases} u_{t}=\Delta u-\nabla \cdot (u \chi(v)\nabla v) & \textrm{in}\quad \Omega\times (0,\infty), \\ 0=\Delta v-v+g(u) & \textrm{in}\quad \Omega\times (0,\infty),\\ \end{equation*} in a smooth and bounded domain of . The chemotactic sensitivity is a general nonnegative function from whilst , the production of the chemical signal , belongs to and satisfies , for all , and It is established that no chemotactic collapse for the cell distribution occurs in the sense that any arbitrary nonnegative and sufficiently regular initial data emanates a unique pair of global and uniformly bounded functions which…
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Taxonomy
TopicsMathematical Biology Tumor Growth · Gene Regulatory Network Analysis · Cellular Mechanics and Interactions
