Two-species active transport along cylindrical biofilaments is limited by emergent topological hindrance

TL;DR

This study models two-species active transport along cylindrical biofilaments, revealing emergent topological hindrance that causes unique jamming and pattern formation, differing from single-species systems and impacting biological transport processes.

Contribution

The paper introduces a novel lattice gas model for two-species transport on cylinders, highlighting how topological constraints fundamentally alter collective behavior compared to traditional models.

Findings

Identifies a jamming transition at sub-maximal densities.

Shows non-equilibrium pattern formation due to species interactions.

Demonstrates robustness of phenomena with biological features.

Abstract

Active motion of molecules along filamentous structures is a crucial feature of cell biology and is often modeled with the paradigmatic asymmetric simple exclusion process. Motivated by recent experimental studies that have addressed the stepping behavior of kinesins on microtubules, we investigate a lattice gas model for simultaneous transport of two species of active particles on a cylinder. The species are distinguished by their different gaits: While the first species moves straight ahead, the second follows a helical path. We show that the collective properties of such systems critically differ from those of one-species transport in a way that cannot be accounted for by standard models. This is most evident in a jamming transition far below full occupation, as well as in non-equilibrium pattern formation. The altered behavior arises because - unlike the case in single-species transport - any given position may be targeted by two particles from different directions at the same time. However, a particle can leave a given position only in one direction. This simple change in connectivity significantly amplifies the impact of steric interactions and thus becomes a key determinant of mixed species transport. We computationally characterize this type of hindrance and develop a comprehensive theory for collective two-species transport along a cylinder. Our observations show high robustness against model extensions that account for additional biomolecular features and demonstrate that even small fractions of a second species can significantly alter transport. This suggests that our analysis is also relevant in a biological context.