Transient drift of Escherichia coli under diffusing Step nutrient profile

TL;DR

This study investigates the time-dependent drift behavior of E. coli bacteria in response to a diffusing nutrient gradient, combining experiments, theory, and simulations to reveal new insights into bacterial chemotaxis dynamics.

Contribution

It introduces a detailed analysis of transient bacterial drift under a diffusing nutrient profile, integrating experimental data with theoretical and simulation models.

Findings

Excellent agreement between experiments, theory, and simulations.

Revealed time-responsive features of bacterial drift.

Implications for understanding bacterial migration and therapeutic responses.

Abstract

Bacteria such as Escherichia coli (E. coli) exhibit biased motion if kept in a spatially non-uniform chemical environment. Here, we bring out unique time-dependent characteristics of bacterial chemotaxis, in response to a diffusing spatial step ligand profile. The experimentally obtained temporal characteristics of the drift velocity are compared with the theoretical and Monte-Carlo simulation based estimates, and excellent agreements can be obtained. These results bring in new insights on the time-responsive facets of bacterial drift, bearing far reaching implications in understanding their migratory dynamics in the quest of finding foods by swimming toward the highest concentration of food molecules, or for fleeing from poisons, as well as towards the better understanding of therapeutic response characteristics for certain infectious diseases.