Calibration for computer experiments with binary responses and application to cell adhesion study

TL;DR

This paper introduces a new calibration framework for binary responses in computer experiments, demonstrated through a cell adhesion study, enabling estimation of kinetic parameters that are hard to measure physically.

Contribution

It develops a novel calibration method specifically for binary responses, extending calibration techniques beyond continuous data.

Findings

Successful application to T cell adhesion data

Estimated kinetic parameters that are difficult to measure physically

Provides scientific insights into cell adhesion processes

Abstract

Calibration refers to the estimation of unknown parameters which are present in computer experiments but not available in physical experiments. An accurate estimation of these parameters is important because it provides a scientific understanding of the underlying system which is not available in physical experiments. Most of the work in the literature is limited to the analysis of continuous responses. Motivated by a study of cell adhesion experiments, we propose a new calibration framework for binary responses. Its application to the T cell adhesion data provides insight into the unknown values of the kinetic parameters which are difficult to determine by physical experiments due to the limitation of the existing experimental techniques.