Adaptive Critical Value for Constrained Likelihood Ratio Testing
Diaa Al Mohamad, Jelle J. Goeman, Erik W. van Zwet, Eric A., Cator

TL;DR
This paper introduces a new, simpler, and more powerful method for constrained likelihood ratio testing that uses a data-dependent chi-squared quantile, improving finite-sample significance control and power especially for sparse alternatives.
Contribution
The authors propose a novel testing procedure that replaces mixture chi-square distributions with a single data-dependent chi-squared quantile, enhancing simplicity and power in constrained hypothesis testing.
Findings
The new test maintains valid finite-sample significance levels.
It offers increased power for sparse alternatives compared to classical methods.
The approach is easier to implement, avoiding complex weight calculations.
Abstract
We present a new way of testing ordered hypotheses against all alternatives which overpowers the classical approach both in simplicity and statistical power. Our new method tests the constrained likelihood ratio statistic against the quantile of one and only one chi-squared random variable with a data-dependent degrees of freedom instead of a mixture of chi-squares. Our new test is proved to have a valid finite-sample significance level and provides more power especially for sparse alternatives (those with a few or moderate number of null constraints violations) in comparison to the classical approach. Our method is also easier to use than the classical approach which requires to calculate or simulate a set of complicated weights. Two special cases are considered with more details, namely the case of testing orthants and the isotonic case of testing…
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Taxonomy
TopicsStatistical Methods in Clinical Trials · Statistical Methods and Inference · Bayesian Methods and Mixture Models
