Subdivisions of the posteromedial cortex in disorders of consciousness

TL;DR

This study identifies specific subdivisions of the posteromedial cortex and their white matter connections to the thalamus that are associated with disorders of consciousness, highlighting their role in brain connectivity impairments.

Contribution

It is the first to demonstrate that dorsal and posterior PMC subdivisions' tracts to the thalamus are linked to DOCs, emphasizing functional heterogeneity.

Findings

Reduced white matter integrity in dorsal/posterior PMC in DOC patients

Impaired functional fluctuations in specific PMC subdivisions

Tracts from these subdivisions to the thalamus are associated with consciousness levels

Abstract

Evidence suggests that disruptions of the posteromedial cortex (PMC) and posteromedial corticothalamic connectivity contribute to disorders of consciousness (DOCs). While most previous studies treated the PMC as a whole, this structure is functionally heterogeneous. The present study investigated whether particular subdivisions of the PMC are specifically associated with DOCs. Participants were DOC patients, 21 vegetative state/unresponsive wakefulness syndrome (VS/UWS), 12 minimally conscious state (MCS), and 29 healthy controls. Individual PMC and thalamus were divided into distinct subdivisions by their fiber tractograpy to each other and default mode regions, and white matter integrity and brain activity between/within subdivisions were assessed. The thalamus was represented mainly in the dorsal and posterior portions of the PMC, and the white matter tracts connecting these subdivisions to the thalamus had less integrity in VS/UWS patients than in MCS patients and healthy controls, as well as in patients who did not recover after 12 months than in patients who did. The structural substrates were validated by finding impaired functional fluctuations within this PMC subdivision. This study is the first to show that tracts from dorsal and posterior subdivisions of the PMC to the thalamus contribute to DOCs.