A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing

TL;DR

This paper introduces a mathematical framework for personalized dosing of CAR T cells, aiming to optimize treatment efficacy and safety based on dynamical systems theory.

Contribution

It presents a novel mathematical approach to personalize CAR T-cell dosing, bridging immunotherapy and dynamical systems modeling.

Findings

Proposes a dynamical systems model for CAR T-cell therapy

Suggests personalized dosing strategies based on model predictions

Lays groundwork for optimizing CAR T-cell treatment protocols

Abstract

Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathematical basis for personalized dosing of CAR T cells is introduced.